FOXBOROUGH, Mass. -- Wide receiver Mario Manningham's shoulder injury will keep him out of the 49ers' game Sunday against the New England Patriots, the 49ers announced Saturday night.

It will be the third game Manningham has missed this season because of the injury he sustained on the first snap of an Oct. 14 loss against the New York Giants, his former team. Manningham made an epic sideline catch in last season's Super Bowl to help the Giants defeat the Patriots.

Manningham also missed last Sunday's win over the Miami Dolphins, and he was limited in practice this past week.

Manningham's absence likely will mean another chance for rookie A.J. Jenkins to not only get on the field but also make his first career catch. Jenkins played a few snaps last Sunday but didn't see any passes come his way -- although Colin Kaepernick appeared to be eyeing him on one play that resulted in a sack.

  • The Patriots reportedly plan to honor the victims the Newtown, Conn., school shooting.

    During a pregame moment of silence, the Patriots will send up 26 red flares, one at a time, according to NFL.com.

    The Patriots -- and New York Giants, who visit the Atlanta Falcons -- also will wear a helmet decal in honor of Newtown, site of the Sandy Hook Elementary School tragedy on Friday.


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    The 49ers will not be wearing the same decal on their helmets, according to a team spokesman, noting that the Patriots and Giants have fan bases in the Newtown region.

  • Local television weather forecasts are calling for temperatures in the mid-30s at kickoff with 5-10 mph winds. It promises to be cold and wet, possibly with light snow.

  • The 49ers are 3-0 against AFC East teams this season, having won by a combined score of 106-16 against the New York Jets, Buffalo Bills and Miami Dolphins.

    The Patriots already have clinched the AFC East and are 5-0 against those same teams. They beat the Bills twice (52-28, 37-31), the Jets twice (29-26 OT, 49-19) and the Dolphins (23-16; they visit Miami in the regular-season finale).