SANTA CLARA -- Tramaine Brock has been honored as the NFC's Defensive Player of the Week, the first 49ers defensive back to win that honor since 2006.

Brock made two interceptions and returned the first for a touchdown that sparked Sunday night's 34-3 rout of the Houston Texans.

Walt Harris, by way of his three interceptions in a 2006 win over the Raiders, was the last 49ers defensive back to win the NFC's weekly honor. Other 49ers cornerbacks so honored: Eric Wright (1988), Deion Sanders (1994), Rod Woodson (1997) and Ahmed Plummer (2003).

Brock's interceptions came as he replaced Nnamdi Asomugha for a second straight game in the nickel back role. Brock last served in that capacity at the start of the 2011 season, when he had an interception in each of the first two games before sustaining a season-ending hand injury.

San Francisco 49ers’ Tramaine Brock (26) intercepts a ball, which he would return for a touchdown, thrown by Houston Texans’ starting
San Francisco 49ers' Tramaine Brock (26) intercepts a ball, which he would return for a touchdown, thrown by Houston Texans' starting quarterback Matt Schaub (8) in the first quarter at Candlestick Park in San Francisco, Calif., on Sunday, Oct. 6, 2013. (Nhat V. Meyer/Bay Area News Group) ( Nhat V. Meyer )

Brock's 18-yard interception return for a touchdown Sunday night came on Matt Schaub's first pass. It also set a dubious NFL record for Schaub, who's had a pass intercepted and returned for a touchdown in four straight games. The 49ers' last scored off interceptions last season, when both Ahmad Brooks and Donte Whitner returned their interceptions for touchdowns in a Nov. 25 win at New Orleans.

Tarell Brown was the last 49er to produce two interceptions in a game, doing so in the 2011 regular-season finale at St. Louis.

Brock was an undrafted rookie in 2010 out of Belhaven (Miss.), which retired his jersey in February 2011.

"Really pleased with the way Tramaine's ascending," 49ers coach Jim Harbaugh said Monday. "When you play like that you're going to continue to play. So, I think there's going to be more opportunity for him."

The next opportunity comes Sunday, when the 49ers (3-2) welcome the Arizona Cardinals (3-2) into Candlestick Park.

For more on the 49ers, see Cam Inman's Hot Read blog at blogs.mercurynews.com/49ers. Follow him on Twitter at twitter.com/CamInman.