SANTA CLARA -- Colin Kaepernick chose one word to sum up the 49ers' rivalry with the Seattle Seahawks: "Physical."

Kaepernick will be seeking his first win in three starts against the Seahawks when the NFC West powers meet Sunday at Candlestick Park.

The 49ers lost the past two meetings, both in Seattle, by a combined score of 71-16, including a 29-3 loss Sept. 15.

"For me, they're just another team in our path on where we want to go," Kaepernick said Wednesday.

If the 49ers lose Sunday, the Seahawks (10-1) will win the NFC West and end the 49ers' two-year reign atop the NFL's toughest division. A Seahawks victory would be their first at Candlestick Park since 2008.

San Francisco 49ers’ Colin Kaepernick (7) throws a pass against the St. Louis Rams in the fourth quarter at Candlestick Park in San Francisco,
San Francisco 49ers' Colin Kaepernick (7) throws a pass against the St. Louis Rams in the fourth quarter at Candlestick Park in San Francisco, Calif., on Sunday, Dec. 1, 2013. The 49ers won, 23-13. (Josie Lepe/Bay Area News Group)

Kaepernick's career-worst game from a statistical standpoint came in that Week 2 loss at Seattle, when he was was 13-of-28 for 127 yards with no touchdowns, three interceptions and a 20.1 passer rating.

"Home-field advantage is always a big thing," Kaepernick said of playing in San Francisco rather than the loud CenturyLink Field. "You get to use cadence and audibles you can't use on the road if you can't hear."

Kaepernick conducted his weekly press conference in the locker room corner that houses his offensive linemen, many of whom rolled their eyes when he brought the 30-reporter cluster into their domain. Alex Boone, who might start at left tackle in place of the injured Joe Staley, told Kaepernick he would be fined for invading their space with media.

Asked why it seems he despises press conferences, Kaepernick replied: "I signed a contract to play football. The media is just an obligation I have to do."