SANTA CLARA -- Come Wednesday, the 49ers will learn what course they must set for their first Super Bowl win in 20 years. It'll be schedule-release day (5 p.m., PT).

It won't be an easy path to Super Bowl XLIX in Glendale, Ariz.

The 49ers rank in the top five for strength-of-schedule in 2014. Their upcoming opponents had a .563 winning percentage last season, tied for the fourth-highest mark with the San Diego Chargers. The three teams ahead of them are on the 49ers schedule: Raiders (.578), Denver Broncos (.570) and St. Louis Rams (.564).

Unlike last season, when the 49ers traveled conceivably more miles than any club in NFL history, this season will be more mileage friendly. Their only game in the Eastern Time Zone is against the New York Giants, and their next furthest games are those on the Mississippi River shores in St. Louis and New Orleans.

Of course, this is the 49ers' first season at the nearly completed Levi's Stadium, a $1.3 billion venue next to their long-time training facility in Santa Clara. Their regular-season home opener is not expected until Week 2, likely on NBC's "Sunday Night Football."

Here's a look at their 16 games, ranked by potential intrigue in each matchup:

1. At Seattle Seahawks: Site of last season's end (and fateful end-zone interception).

2. Vs. Seattle Seahawks: They may be reigning champs but they haven't won in the Bay Area since 2008 -- or in 2,004 days.

3. At Denver Broncos: It's the Super Bowl runner-up show!

4. At Raiders: Rare Coliseum visit. Matt Schaub, watch out for Tramaine Brock this time.


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5. Vs. Kansas City Chiefs: Welcome home, er, back Alex Smith.

6. At New Orleans Saints: Ahmad Brooks & Co. return to the scene of last year's crime (not to be confused with this offseason's crime wave.)

7. At Arizona Cardinals: Toughest division game outside of Seahawks matchups.

8. Vs. Philadelphia Eagles: Chip Kelly's fast-paced offense vs. the 49ers' elite but evolving defense.

9. At Dallas Cowboys: Classic rivalry, and first 49ers trip to Jerry's World -- outside of 2009 exhibition.

10. Vs. Chicago Bears: They were Colin Kaepernick's prey for his first career start.

11. At New York Giants: Will Eli Manning's ankle be up for this always-theatrical matchup.

12. Vs. Washington Redskins: Robert Griffin III floundered last season vs. the 49ers, but this time he has DeSean Jackson.

13. Vs. Arizona Cardinals: How did this division rival miss the playoffs last season with a 10-6 mark? Answer: 2-4 in NFC West.

14. Vs. St. Louis Rams: Did you know the Rams (L.A., version) spoiled the 49ers' Candlestick debut?

15. Vs. San Diego Chargers: Yes, it's coming on 20 years since the 49ers beat them in the Super Bowl.

16. At St. Louis Rams: They may play the 49ers tough, but the Rams haven't had a winning season since 2003 (circa: Dennis Erickson era).