Sandusky, who ran G3 Holistic Inc. in Upland, Colton and Moreno Valley and a warehouse in Ontario, is facing six counts of drug trafficking, which can carry a sentence of 10 years to life in prison.
"One warehouse, three retail stores and over 1,000 marijuana plants - evidence for a reason why the defendant is guilty as charged," said Assistant U.S. Attorney Jay Robinson in his opening statement, which outlined an alleged conspiracy among Sandusky and other defendants to cultivate and sell marijuana through the cooperatives.
State voters in 1996 approved Proposition 215, which allows the use and sale of medical marijuana in the state.
U.S. District Judge Percy Anderson told jurors not to consider the state's laws on medical-marijuana use, because all marijuana use is illegal under federal law.
Sandusky and five others affiliated with G3 were arrested and indicted in June on federal drug-trafficking charges as well as conspiracy to manufacture and possess with intent to distribute marijuana.
The defendants, including Sandusky's brother Keith, were also charged with possession with intent to distribute marijuana.
G3 co-founder John Leslie Knuckolls II, 31, of Rialto and warehouse worker Richard Irwin Kirchnavy, 45 of Rancho Cucamonga have pleaded guilty and will be called to testify during the two- to four-day trial, Robinson said.
Sandusky is also expected to testify.
Sandusky's attorney, Roger Jon Diamond, will give his opening statement today.
The trial continues at 8 a.m. today, and the jury is expected to begin deliberations on Friday.
Reach Sandra via email, call her at 909-483-8555, or find her on Twitter @UplandNow .