The crash, which was reported at about 3:16 p.m., took place near Palo Verde Avenue and Wardlow Road, said Lisa Massacani, a Long Beach Police Department spokeswoman.
The initial investigation found the driver of a Toyota Tundra was traveling south on Palo Verde and the driver of a Toyota Corolla was heading west on Wardlow when the two vehicles collided at the intersection, Massacani said.
A Mercury Mountaineer that was stopped at a light was then struck by the Corolla, which went spinning after the initial impact.
Among the three cars, five people were treated by firefighters and paramedics. Four of the people, two women and two children, were taken to local trauma centers with moderate injuries based on the force the impact, said Firefighter Will Nash, an LBFD spokesman.
"None of the injuries appear to be life-threatening," he said.
The intersection was briefly shut down as investigators reviewed the scene and both the Tundra and the Corolla had to be towed away, Massacani said.
No one was cited, but the investigation is ongoing, she said.