Bobo, 74, needs 24-hour care in her Claremont residence and has Parkinson's disease, arthritis and other ailments.
The Saturday sale, hosted by friend Ann Kroutil Donnan, will be at Donnan's home at 265 W. 11th St., Claremont.
People and merchants are welcome to donate items or food to benefit Bobo, whose friends, former students and family are trying to raise $72,000 to keep her in her home to reach her 80th birthday.
"She really is a wonderful person," Donnan said on Tuesday. "And it's helping a lot."
Donnan said there had been approximately $10,000 raised so far.
In a recent interview, Bobo she has to be "watched every second of my life" by six caretakers. "They have to be available in case I have a gastro-intestinal problem. I can't fix myself a cup of tea. I really can't do anything."
Donnan said there will be free coffee in the morning with pastries for sale and a garage sale ongoing.
After noon, there will be pizzas ordered and made available for sale, Donnan said.
People are encouraged to bring items to donate and "clean out their closet," Donnan said.
Donnan added businesses could donate items and she would like people to call her by Friday to let her know what they would bring.
"She greatly appreciated the help she received so far," Donnan said of Bobo. "Both former students and people who don't know her. It's been just wonderful."
Bobo said in a previous interview she is not ready for a nursing home.
"I don't think I could get anything that attentive in a home. I'm not really ready for the nursing home ... mentally I'm not ready."
Contributions can also be given online at http://ruthmbobofund.com/ or sent to her home at Ruth M. Bobo Fund, 580 W. 10th st. Claremont 91711.
"She was definitely a great teacher," said former student Arin Allen in a previous interview. "And I think one of the most memorable. A handful of teachers I remember who they are. With Mrs. Bobo, she's got a lot of character."
Added Donnan in a previous interview: "She's cheerful, hardworking, loving, kind, everyone adores her, She speaks with a sweet Alabama accent that reminds us all of William Faulkner. She's our very own Southern belle and Alabama peach."
For more information on the sale, contact 909-625-1998.