The men got into Walde's Desert Pharmacy in the 9700 block of Sierra Vista Road in the early morning, stole medication and fled.
The incident was captured on surveillance video, San Bernardino County sheriff's officials said.
Anyone with information may call deputies at 760-868-1006 or WeTip, 800-78-CRIME.
Reach Melissa via email or call her at 909-386-3878.
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