The incident happened at 9:40 a.m. in the 12000 block of Mulholland Drive just west of Skyline Drive, leaving the woman trapped in her vehicle against a tree for nearly an hour, said LAFD spokesman Erik Scott.
Firefighters found the woman hanging by her seatbelt, upside down. Fire officials say her seatbely probably saved her from being ejected from her car as it tumbled down the hillside.
The rescue took the efforts of 50 firefighters to help secure the car and the safely extricate the woman from her vehicle, Scott said. They had to carry her some 300 feet up a muddy hillside.
The condition and identity of the woman has not been released, but she was transported to a local hospital.
There was no passenger or others involved in the crash.