SANTA CLARA -- The 49ers will have the rival Seattle Seahawks over for Thanksgiving dinner, highlighting Levi's Stadium's debut schedule. Plenty of pageantry is sure to also come Sept. 14, with the 49ers' official home opener against the Chicago Bears.

Those are the only two prime-time home games on the 49ers' regular-season schedule, which was unveiled Wednesday.

The 49ers will open on the road for the second time in coach Jim Harbaugh's four seasons, this time against the Dallas Cowboys on Sept. 7. It'll be the 49ers' first regular-season trip to AT&T Stadium, a $1.2 billion venue that opened in 2009.

Then it's time for the $1.3 billion Levi's Stadium to enter the NFL spotlight, even if two exhibitions already will have been held there in August against the Denver Broncos and San Diego Chargers.

After hosting the Bears on NBC's "Sunday Night Football," Levi's Stadium will welcome in the Philadelphia Eagles (Sept. 28), Kansas City Chiefs (Oct. 5), St. Louis Rams (Nov. 2), Washington Redskins (Nov. 23), Chargers (Saturday, Dec. 20) and Arizona Cardinals (Dec. 28).

The Nov. 27, Thanksgiving night game features arguably the league's hottest rivalry. The Seahawks beat the 49ers in last season's NFC Championship game 23-17 before routing the Denver Broncos 43-8 in Super Bowl XLVIII.

Linebacker Patrick Willis said "it doesn't matter" to him or the 49ers that their rematch with the Seahawks doesn't come until November. "It just happens to be on this kind of (prominent) stage and we'll look forward to it when the time comes," Willis said on NFL Network.

Another reason to look forward to that game: The 49ers might have linebacker NaVorro Bowman back from reconstructive knee surgery.

The 49ers have never hosted a Thanksgiving game, and they last played on that holiday in 2011, losing 16-6 at Baltimore.

After traveling more air miles last season than conceivably any team in NFL history, the 49ers have only one Eastern Time Zone game: at the New York Giants on Nov. 16. Their next farthest games are those on the Mississippi River shores in St. Louis (Oct. 13) and New Orleans (Nov. 9).

On Dec. 7, the 49ers visit Oakland in regular-season action for the first time since 2002 -- a 23-20 overtime win by the 49ers -- and only the fourth time series history. The other two regular-season visits came in 1970 and '79.

The 49ers' remaining road schedule pits them against the Cardinals (Sept. 21), Rams (Oct. 13), Denver Broncos (Oct. 19), and Seahawks (Dec. 14). Week 8 serves as the 49ers' bye. They play back-to-back road games three times.

For the second straight season, the 49ers' visit to St. Louis falls in prime-time ("Monday Night Football" this year, "Thursday Night Football" last year). The 49ers-Broncos game is slated for "Sunday Night Football," although that could change under the league's flexible-schedule rules that go into effect in Week 5.

The 49ers are 10-3 in prime time under Harbaugh, including marks of 4-1 last season and 5-1 in 2012 when their only such losses came at Seattle. The 49ers have reached the NFC Championship game in each of Harbaugh's three seasons, with a Super Bowl XLVII defeat sandwiched between two losses in the NFC finals.

Before the regular season opens, the 49ers will break in Levi's Stadium with exhibitions on back-to-back Sundays against the Broncos (Aug. 17) and San Diego Chargers (Aug. 24). Both games start at 1 p.m., and they're sandwiched between road exhibitions at Baltimore (Aug. 7) and Houston (Aug. 28).

The 49ers rank in the top five for strength-of-schedule. Their upcoming opponents had a .563 winning percentage last season, tied for the fourth-highest mark with the Chargers. The three teams ahead of them are on the 49ers schedule: Raiders (.578), Broncos (.570) and Rams (.564).