ANTIOCH -- A man and woman were hospitalized early Tuesday for major injuries suffered in a one-car crash on eastbound Highway 4, the California Highway Patrol said.

Officers were called to a crash just west of state Highway 160 at 12:52 a.m. and found a damaged Dodge Intrepid, CHP Officer John Fransen said. The sedan hit a barrier on the freeway, though the cause remains under investigation, he said.

A helicopter took one of the injured people to John Muir Medical Center in Walnut Creek; the other was taken by ambulance to the same hospital. Both suffered major injuries, Fransen said.

The crash scene was not cleared for two hours.

Contact Rick Hurd at 925-945-4789 and follow him at Twitter.com/3rdERH.