Justice Minister Nestor Reverol announced Sunday's bust on television, saying the truck was stopped at a checkpoint in western Lara state. He says the cocaine came from neighboring Colombia and the Venezuelan driver was arrested.
Officials showed the truck with its side cut open to reveal a compartment behind the cab where the cocaine was hidden.
Venezuela has been a major route for cocaine trafficking in recent years. U.S. and Colombian officials have said a majority of northbound smuggling flights originate in the country.
Reverol says the bust is one of many that have shown his government's commitment to combatting the flow of drugs.