NEW YORK -- Once again, John Isner's trip to Flushing Meadows ended in the third round. Once again, it happened with a loss to Germany's Philipp Kohlschreiber at that stage.
And once again, there are zero American men in the U.S. Open's round of 16 -- something that had never happened until it did last year at the country's tennis championship, which was first played in 1881.
On a windy, cloudy evening, the 13th-seeded Isner hit 42 aces, saved all five break points he faced -- and yet it wasn't enough. Unable to capitalize on plenty of openings, and surprisingly outplayed in a trio of tiebreakers, Isner lost to the 22nd-seeded Kohlschreiber 7-6 (4), 4-6, 7-6 (2), 7-6 (4).
"It's disappointing for me personally -- not for America as a whole," Isner said.
It was the third straight year that these two men faced each other in the third round in New York, and Kohlschreiber won them all. He eliminated the big-serving, 6-foot-10 Isner in five sets in 2012, and in four sets in 2013.
Isner only converted 1 of 12 break points he accumulated.
"Got a little tight, to be honest, and didn't move my feet on some points that I really needed," Isner said, resting his chin on his left fist. "I had chances. I just didn't convert."
The 29-year-old Isner is best known for winning the longest match in tennis history, an 11-plus-hour marathon spread over three days that ended 70-68 in the fifth set at Wimbledon in 2010.
Earlier Saturday, 57th-ranked Sam Querrey -- entering the day, the only other man from the host country remaining of the 12 originally in the draw -- put up little resistance while bowing out against No. 1 Novak Djokovic 6-3, 6-2, 6-2.
Other fourth-round matchups: No. 3 Stan Wawrinka, the Australian Open champion, against No. 16 Tommy Robredo; 2012 U.S. Open champion Andy Murray against No. 9 Jo-Wilfried Tsonga and No. 5 Milos Raonic against No. 10 Kei Nishikori. Wawrinka advanced when Blaz Kavcic withdrew because of pain in his right foot.
Given Isner's history against Kohlschreiber at the U.S. Open, it's tough to call that result surprising, even if the American is ranked higher and is 4-0 against the German everywhere else they've played.
Instead, look to the women for the "Did that really happen?" results. In the latest of a series of stunners, third-seeded Petra Kvitova -- who won her second Wimbledon title last month -- was sent home with a 6-4, 6-4 defeat against Aleksandra Krunic, a 21-year-old qualifier from Serbia who is ranked 145th.
That means that the women seeded 2, 3 and 4 behind No. 1 Serena Williams are all gone before the end of Week 1.
"I'm an outsider," Krunic said. "I honestly didn't know what to expect from myself at all. You know, I don't know my limits."
Of the top eight women, only Williams, No. 5 Maria Sharapova and No. 7 Eugenie Bouchard remain. Bouchard, the runner-up to Kvitova at Wimbledon, reached the fourth round at the U.S. Open for the first time by beating 30th-seeded Barbora Zahlavova Strycova 6-2, 6-7 (2), 6-4.
Williams, the two-time defending champion, is the last American singles player left; there were 17 in the women's draw, and she's beaten three, including a 6-3, 6-3 victory against 2012 Olympic teammate and occasional practice partner Varvara Lepchenko.
Williams meets 50th-ranked Kaia Kanepi of Estonia, who knocked out No. 15 Carla Suarez Navarro 7-5, 6-0. Other women's fourth-round matchups: Bouchard against No. 17 Ekaterina Makarova, No. 11 Flavia Pennetta against No. 29 Casey Dellacqua, and Krunic against two-time U.S. Open runner-up Victoria Azarenka.
The tournament run of former Stanford player Nicole Gibbs ended when she was beaten by No. 11-seed Flavia Pennetta 6-4, 6-0.
Stanford products and top seeds in the men's doubles, Bob and Mike Bryan, won their second-round match, downing Americans Jared Donaldson and Michael Russell 6-1, 6-2.