Things just got a lot tougher for the struggling New York Jets.
Wide receiver Santonio Holmes will miss the rest of this season with an injured left foot, leaving the Jets without their top offensive playmaker. The team announced Wednesday that Holmes will require surgery, and he was placed on season-ending injured reserve.
"Obviously, that's a big loss for us," coach Rex Ryan said. "Santonio's one of the top receivers in the game, and it is a big loss."
The news came just over a week after star cornerback Darrelle Revis was likely lost for the season with a torn ligament in his left knee -- although the Jets haven't placed him on IR yet.
But that leaves the Jets (2-2) now without their best players on defense and offense as they try to return to the playoffs this year after missing out last season.
"Woe is me?" Ryan said defiantly. "How many people are going to feel sorry for the New York Jets? Myself, I know the answer to that: Nobody."
Holmes went down on the first play of the fourth quarter of the Jets' 34-0 loss to the 49ers on Sunday after catching a short pass that he tossed away for a fumble that was returned 51 yards for a touchdown by Carlos Rogers.
Titans: Jake Locker's left shoulder is sore enough that the team doesn't even want him dressing Sunday when it visits Minnesota, so veteran Matt Hasselbeck will start at quarterback. Whether Locker misses more than one game depends on how quickly his non-throwing shoulder heals.
Locker dislocated the shoulder for the second time in four games when sacked in last week's 38-14 loss at Houston.
Cardinals: Arizona quarterback John Skelton is listed as questionable for Thursday night's game at St. Louis even though he fully participated in the team's last two practices.
Skelton sprained his right ankle in the season opener against Seattle. Kevin Kolb relieved him and has led the Cardinals to their first 4-0 start in 38 years.
In all, nine Arizona players were listed as questionable, including defensive tackle Darnell Dockett (hamstring), running back LaRod Stephens-Howling and tight end Todd Heap (knee).
Bills: Buffalo defensive tackle Kyle Williams is questioning why he's been fined $15,000 by the NFL for a roughing-the-passer penalty against New England's Tom Brady. Williams intends to appeal the fine, questioning what he did wrong when attempting to make a tackle while Brady still had the ball.
Hurd case: Former NFL receiver Sam Hurd pleaded not guilty to a new indictment accusing him of trying to obtain cocaine and marijuana while he was out on bond awaiting trial on charges of trying to start a drug ring in the Chicago area.