Achraf Yacoubou hit the tiebreaking 3-pointer with 3:57 left to help Villanova upset No. 5 Louisville 73-64 on Tuesday night in Philadelphia.
The Wildcats (12-7, 3-3 Big East) led by as many as 10 points in the first half and rallied late in the second to send the Cardinals to their second straight loss. Louisville (16-3, 4-2) had an 11-game winning streak end in a 70-68 loss to Syracuse on Saturday.
Ryan Arcidiacono scored 15 points, and JayVaughn Pinkston and Mouphtaou Yarou each scored 11 for Villanova.
"I just felt we broke through tonight," Arcidiacono said. "We just kept grinding, kept grinding. I didn't have any doubts we were going to win this game."
"We know how good they are," Wildcats coach Jay Wright said of Louisville. "We still think that team can win a national championship."
Peyton Siva had 15 points and 13 assists for the Cardinals, and Wayne Blackshear scored 17 points. Louisville was 12 of 24 from the free-throw line.
"We did a lot of things wrong tonight, and they did a lot of things right," Cardinals coach Rick Pitino said. "It was really a simple answer as to why we lost. Our free throws were a turnover. Our foul shooting was despicable. Very simple tonight."
Kansas 59, Kansas State 55: Travis Releford scored 12 points and the No. 3 Jayhawks (17-1, 5-0 Big 12) held off the host No. 11 Wildcats (15-3, 4-1) down the stretch.
Kansas State lost for the 45th time in its past 48 games against its in-state rival.
Michigan State 49, Wisconsin 47: Keith Appling scored 19 points and Branden Dawson added 18 to help the No. 13 Spartans (17-3, 6-1 Big Ten) defeat the host Badgers (13-6, 4-2).
Ohio State 72, Iowa 63: Deshaun Thomas, who missed part of the second half with a cut above his eye, scored 16 points as the No. 14 Buckeyes (14-4, 4-2 Big Ten) built a big lead and then held off the visiting Hawkeyes (13-6, 2-4).
Wake Forest 86, North Carolina State 84: Freshman Devin Thomas had a season-high 25 points, 14 rebounds and four blocks to spark the host Demon Deacons (10-8, 3-3 Atlantic Coast Conference) past the No. 18 Wolfpack (15-4, 4-2).
N.C. State, which led by 16 points in the first half and 12 at halftime, fell to 1-2 since upsetting top-ranked Duke on Jan. 12.
Missouri 71, South Carolina 65: Earnest Ross and Jabari Brown hit late 3-pointers as the No. 22 Tigers (14-4, 3-2 Southeastern Conference) overcame 5-for-27 shooting from long range and a 13-point second-half deficit to defeat the visiting Gamecocks (11-7, 1-4).
Ross had a career-best 21 points and Brown had 17 for Missouri.