Top-ranked Duke went more than 8 minutes without a field goal in the first half Wednesday night, and a sellout became a blowout for No. 25 Miami, which delighted a boisterous crowd with a 90-63 victory.
The defeat was the third-worst ever for a No. 1 team. The last time Duke lost a regular-season game by a bigger margin was in January 1984.
"It wasn't demoralizing; they played better," said Duke's Rasheed Sulaimon, who scored 16 points.
Durand Scott scored 25 points for Miami (14-3, 5-0 Atlantic Coast Conference), which took control with a 25-1 run midway through the opening half.
Seth Curry, Tyler Thornton and Quinn Cook went a combined 1 for 29 from the field for Duke (16-2, 3-2).
La Salle 54, Butler 53: With his team out of timeouts, Ramon Galloway sprinted the length of the court for the winning basket with 2.7 seconds left to lift La Salle over the No. 9 Bulldogs (16-3, 3-1 Atlantic 10) in Philadelphia.
It was the first time since 1980 that the Explorers (13-5, 3-2) defeated a top 10 team.
Santa Clara 66, CS Bakersfield 36: Marc Trasolini had 14 points and 10 rebounds to help the host Broncos (15-6)
Raymond Cowels III added 11 points for SCU, which led 31-13 at halftime.
Oregon 68, Washington State 61: E.J. Singler scored 19 points and the No. 16 Ducks (17-2, 6-0 Pac-12) rallied from a 10-point halftime deficit to beat the visiting Cougars (10-9, 1-5).
Oregon State 74, Washington 66: Devon Collier had 16 points to lead the host Beavers (11-8, 1-5 Pac-12) past the Huskies (12-7, 4-2).
Baylor 66, Iowa State 51: Brittney Griner scored 22 points, blocked six shots and dunked for the 11th time in her career in leading the No. 1 Lady Bears (17-1, 7-0 Big 12) past the host Cyclones (13-4, 4-3).