After three years of last-second shots and steals that always seemed to go USF's way, Gonzaga coach Mark Few felt uneasy until the final buzzer sounded at War Memorial Gymnasium.
But unlike the past three seasons when the Dons stunned the Bulldogs at The Hilltop, Gonzaga's big men Kelly Olynyk and Elias Harris overwhelmed diminutive USF when it mattered most, keying a late 11-0 run.
Olynyk had 26 points and nine rebounds, and Harris added 17 points and 13 rebounds to carry the No. 5 Bulldogs past the pesky Dons 71-61 on Saturday. Gonzaga (25-2, 12-0) was the highest-ranked team to visit The Hilltop in 44 years.
"It was, unfortunately, men against boys," USF coach Rex Walters said.
Cole Dickerson had 15 points for the Dons (11-15, 4-9 WCC), who erased a 15-point first-half deficit.
Saint Mary's 61, Loyola Marymount 50: Stephen Holt had 16 points on 6-of-8 shooting to help the visiting Gaels (22-5, 11-2 WCC) beat the reeling Lions (8-12, 1-12). LMU led 7-4 4 minutes into the game, but Saint Mary's went on a 14-0 run and wasn't seriously threatened again.
Santa Clara 70, Pepperdine 60: Kevin Foster scored 22 points, leading the host Broncos (19-8, 7-5 WCC)
Denver 62, San Jose St. 41: The host Spartans (9-16, 3-11 WAC) trailed 28-14 at halftime to the Pioneers (17-8, 13-2) en route to their 10th loss in a row since leading scorer James Kinney was suspended for academic reasons. LaVanne Pennington led SJSU with eight points.
Oregon 79, Washington State 77: E.J. Singler sank two free throws with 3.8 seconds left in overtime, and the No. 23 Ducks (21-5, 10-3 Pac-12) escaped with a win over the host Cougars (11-15, 2-11). Singler, who finished with 25 points, was fouled by Dexter Kernich-Drew as he dribbled up court. Royce Woolridge had 36 points for the Cougars, who built an 18-point lead in the first half.
Arizona St. 63, Colorado 62: Evan Gordon's buzzer-beating layup in overtime lifted the Sun Devils (19-7, 8-5 Pac-12) past the host Buffaloes (17-8, 7-6). Gordon's basket came after Spencer Dinwiddie's bucket with 8.3 seconds left had given Colorado a 62-61 lead. Gordon had 14 points.
Maryland 83, Duke 81: Seth Allen broke a tie by making two free throws with 2.8 seconds left, and the host Terrapins (18-7, 6-6 ACC) upset the No. 2 Blue Devils (22-3, 9-3). Duke trailed by 10 with 3:39 left but pulled even when Rasheed Sulaimon made three foul shots with 16.7 seconds to go. Quinn Cook then fouled Allen as the freshman drove through the lane. Allen finished with 16 points. Seth Curry had 25 for Duke.
Tennessee 88, Kentucky 58: Trae Golden had 24 points as the host Volunteers (14-10, 6-6 SEC) beat the No. 25 Wildcats (17-8, 8-4), Tennessee's most lopsided win in the 216-game history of this series. Kentucky was playing its first game without star Nerlens Noel (knee injury).
Connecticut 65, Rutgers 45: The No. 3 Huskies (24-1, 11-1 Big East) beat the host Scarlett Knights (14-10, 5-6), denying coach C. Vivian Stringer of her 900th win.
Saint Mary's 49, Portland 43: Danielle Mauldin had 13 points and 11 rebounds, leading the Gaels (17-7, 9-3 WCC) over the host Pilots (10-16, 5-8). Saint Mary's limited Portland to 27.8 percent shooting.
Gonzaga 101, USF 65: Sunny Greinacher led 15 points, and the host Bulldogs (22-5, 12-1 WCC) routed the visiting Dons (10-16, 3-10). Taylor Proctor had 19 points for USF.
Denver 83, San Jose State 68: Ta'Rea Cunnigan had 26 points for the Spartans (9-16, 6-8 WAC), who fell to the host Pioneers (12-14, 7-8. Trailing by as many as 23 points in the first half, San Jose State battled back to tie it at 54-54 midway through the second half.
Wire services contributed to this report.