The Blue Hens (17-3, 8-0 Colonial Athletic Association) won their 27th straight regular-season conference game.
Delle Donne scored 19 of her points in the first half, almost matching the first-half total for the Panthers (10-9, 2-6), as Delaware opened a 40-21 lead. The All-America forward, who hit 9 of 19 shots from the field, played just 8 minutes in the second half.
The Blue Hens dominated the boards, holding a 48-23 rebounding advantage, but Georgia State's Cody Paulk did her best to provide an inside presence for her team. The Panthers' career leader in blocked shots swatted away six, and she also had 13 points and seven rebounds.
Akeema Richards added 10 points and Danielle Parker 10 rebounds for the Blue Hens.