St. Louis quarterback Sam Bradford and Indianapolis wide receiver Reggie Wayne each tore an anterior cruciate knee ligament and will miss the rest of the season.

Bradford's injury is a devastating blow to the Rams, who will turn to backup quarterback Kellen Clemens.

Wayne's injury seriously dampened the Colts' spirits after a big win over Peyton Manning.

Bradford tore the ACL in his left knee, which coach Jeff Fisher said was already in a brace. The former No. 1 overall pick had 14 touchdown passes and just four interceptions in his fourth season.

Wayne tore his right ACL in the fourth quarter of a victory over Denver. The soon-to-be 35-year-old wide receiver had played in 189 consecutive games. Wayne led his team with 38 catches and 503 yards this season. In 13 seasons, all with the Colts, he has 1,006 receptions, 13,566 yards and 80 TD catches.

"Looking back at it again today, there was really no one within 30 yards of him," quarterback Andrew Luck said. "He probably would have scored if I actually give him a decent ball. I feel somewhat responsible for the whole thing. I think I feel sick to my stomach about it a little bit."

In other injury news:


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  • Bears quarterback Jay Cutler will miss at least the next four weeks with a torn groin muscle. Veteran Josh McCown will replace Cutler. Chicago Pro Bowl linebacker Lance Briggs will be out for around six weeks after sustaining a small fracture in his left shoulder.

  • Texans Pro Bowl linebacker Brian Cushing is out for the season with a left knee injury that will require surgery.

  • Eagles quarterback Nick Foles sustained a concussion in a loss to Dallas.

  • Buccaneers running back Doug Martin hurt his left shoulder during in a loss to Atlanta.

    Giants 23, Vikings 7: New York got its first win of the season by holding Adrian Peterson in check and capitalizing on visiting Minnesota's mistakes.

    Peterson was held to 28 yards five days after his 2-year-old son was buried in South Dakota. The man accused in the death was indicted on second-degree murder and manslaughter charges, prosecutors said Monday.

    Peterson was not helped by a rusty Josh Freeman, making his debut as Vikings quarterback after being signed as a free agent when Tampa Bay cut its 2009 first-round draft pick. Freeman frequently missed open receivers, and several of his throws sailed yards beyond his targets.

    Bud Adams dies: Titans owner Bud Adams, who helped found the American Football League and whose battles for players helped lead to the merger with the NFL, has died. He was 90. The team announced that Adams "passed away peacefully from natural causes."

    The son of a prominent oil executive, Adams built his own energy fortune and founded the Houston Oilers. He moved the team to Tennessee in 1997 when he couldn't get the new stadium he wanted in Houston. The franchise, renamed the Titans, in 2000 reached the Super Bowl that Adams had spent more than three decades pursuing, losing 23-16 to St. Louis.

    Adams' 409 wins were the most of any current NFL owner.

  • The Titans have released kick returner Darius Reynaud a day after he muffed a punt in a loss against the 49ers.

    Texans: Coach Gary Kubiak said rookies Cierre Wood, Sam Montgomery and Willie Jefferson were released for violating team rules. He wouldn't specify what the players did.

    Seahawks: Wide receiver Percy Harvin is returning to practice after missing the first seven weeks of the regular season following hip surgery.

    Browns: Coach Rob Chudzinski said he's considering benching starting quarterback Brandon Weeden and starting ex-Raider Jason Campbell on Sunday at Kansas City.

    Trade: Miami acquired veteran tackle Bryant McKinnie from the Baltimore Ravens for a conditional late-round draft pick.