Almost three years after undergoing brain surgery, J.B. Holmes is a winner again on the PGA Tour.

Holmes made it harder than he needed to on the final hole at Quail Hollow until rapping in a 3-foot bogey putt for a 1-under 71 and a one-shot victory over Jim Furyk in the Wells Fargo Championship in Charlotte, N.C. Furyk finished his Sunday-best 65 some two hours earlier.

Jason Bohn had the best chance to catch Holmes. He was one shot behind when he pulled a 4-iron into the water on the par-3 17th, making double bogey. Phil Mickelson never had a chance, missing four putts from the 4-foot range and closing with a 76 to finish out of the top 10.

The win capped a remarkable turnaround for Holmes, who won for the third time in his career.

He was diagnosed in August 2011 with structural defects in the cerebellum known as Chiara malformations, and he had surgery twice -- once to remove a piece of his skull that he still keeps at home, another because of an allergic reaction to the adhesive on the titanium plate at the base of his skull.

Then, he injured his elbow by hitting too many balls in an attempt to return from the surgery. He didn't bother having surgery on his elbow until last year, when he was sidelined by a broken ankle and couldn't play, anyway.

Only last week, Holmes earned enough money to keep his card for the rest of the year from a medical extension. Now, he's headed to The Players Championship next week for the richest prize in golf, and more important, secured a spot in the PGA Championship this summer in his native Kentucky.

"It's been a long journey for me," said Holmes, who finished at 14-under 274. "I've had some ups and downs. It's a great feeling to be out there and to get one done."

His only other victories were in the Phoenix Open in 2006 and 2008.

LPGA: After six runner-up finishes in her previous 16 tournaments, Stacy Lewis took control in the final round of the North Texas Shootout in Irving, shooting a 7-under 64 for a six-stroke victory over Meena Lee.

Lewis finished at 16-under 268 and with the LPGA Tour's largest margin of victory since Jiyai Shin won the 2012 Women's British Open by nine. Michelle Wie, who closed within two before faltering late, had a 67 to finish third at 9 under.

Champions: Bernhard Langer won the Insperity Invitational for the third time, closing with a 1-under 71 for a one-stroke victory over Fred Couples. Langer finished at 11-under 205 at The Woodlands (Texas) Country Club.

Couples finished with a 67, and Colin Montgomerie was third at 9 under after a 70.